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The 11 Best Topical Flea And Tick Treatments For Dogs

It is essential to protect your dog against fleas and ticks, especially if they spend the majority of their time outside.

Fleas and how to get rid of them protect your dog not only from annoying bugs but also from diseases that fleas can spread, like Lyme disease.

However, with so many alternatives available, it might be challenging to pick which one to select.

Pills, chews, ointments, and shampoos are available for flea and tick prevention. Each alternative differs in terms of delivery methods and frequency of usage.

Topical flea and tick treatments are available without a prescription and are one of the most effective ways to protect your dog from fleas and ticks.

BestForPets (bestforpets.org) presents this year's best topical flea and tick treatments for dogs to help you restrict your search.


TevraPet FirstAct Plus Flea & Tick Spot Treatment for Dogs – Lowest Price

TevraPet FirstAct Plus Flea and Tick

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  • Usage: Prevention
  • Lifestage: Adult
  • Product Form: Liquid

TevraPet’s topical, waterproof flea and tick therapy is a preventative measure only. It will not work if your dog already has fleas, but it is quite effective in repelling fleas.

TevraPet FirstAct Plus is the most cost-effective topical flea and tick treatment for dogs. It is far less expensive than other kinds, yet it is still effective.

It comes in packets of three treatments and is waterproof, so there is no need to let the solution dry before applying it.

Please keep your dog away from cats for at least 48 hours after application, since this formula contains chemicals that are toxic to cats.

Some owners in high-risk locations indicate that multiple applications are required for full efficacy.


  • Budget-friendly price tag
  • Waterproof


  • Not permitted in high-risk locations

K9 Advantix II Flea and Tick Spot Treatment for Dogs — Most Beneficial for Puppies

K9 Advantix II Small Dog Vet

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  • Usage: Prevention
  • Lifestage: Adult, puppy
  • Product Form: Answer

A significant proportion of flea and tick medications are contraindicated for puppies, thus it is crucial to read the label and consult your veterinarian for dogs less than 6 months.

K9 Advantix II may be administered to puppies as early as 7 weeks and to adult dogs weighing less than 10 pounds.

This treatment combines three substances to eliminate fleas and ticks at all lifecycle phases. It starts functioning within 12 hours after application and kills on touch.

During flea and tick season, you will need to administer it once every month, but it is one of the few alternatives available for young and extremely small dogs.


  • Safe for pups older than 7 weeks and weighing 4 to 7 pounds
  • Lethal upon touch


  • Must be applied each month
  • Not always lasting the entire month

Frontline Plus Flea and Tick Treatment: Recommended for Large Dogs

FRONTLINE Plus for Dogs Flea and Tick Treatment

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  • Usage: Prevention
  • Existence: adult, puppy
  • Product Form: Answer

Adult fleas and ticks, as well as flea eggs and larvae, are killed by two separate substances in Frontline Plus Flea & Tick Spot Treatment .

It comes in an easy-to-use, snap-open tube. The solution is easily applied between the dog’s shoulder blades, where it is absorbed and stored for up to thirty days.

Frontline is not waterproof until 48 hours after application, therefore you must keep your dog dry for 48 hours after application.

It is also toxic to cats within the first 48 hours, so if you have a cat at home, you should be cautious. Unfortunately, this product also leaves a greasy patch of fur on the back of your dog that does not go.


  • Eliminates fleas at every life stage
  • Simple to employ


  • Leaves oily stains on the coat of your dog
  • Unsafe for felines
  • Not watertight till 48 hours later

Sentry Fiproguard Plus Squeeze-On Flea and Tick Treatment for Dogs: Recommended for Small Dogs

Sentry 3 Count Fiproguard Plus for Dogs Squeeze-On

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  • Treatment and preventive measures
  • Lifestage: Adult
  • Product Form: Liquid

Small dogs do not require the same amount of flea and tick prevention as large dogs, which is why we appreciate this medication from Sentry Fiproguard Plus  that is specially formulated for dogs weighing between 4 and 22 pounds.

It should be treated every 30 days and kills on contact fleas, flea eggs, flea larvae, and lice. This product is waterproof until it has dried, which takes a few hours following application.

One disadvantage of Sentry Fiproguard Plus is that the tubes are difficult to access. They do not open easy, and you will need scissors to do it.

If you cut them too deeply, it is possible to lose the medication or for part of it to leak out, leaving your dog with less than the prescribed amount.

Please note that this formula should not be used on cats, and if you have a cat, it is best to keep it at least 48 hours away from your dog.


  • Specific dosage for little dogs
  • Waterproof once it dries
  • Affordable


  • Monthly application required
  • It is challenging to open application tubes

Topical & Indoor Flea & Tick Spray for Dogs & Cats by Wondercide

Wondercide - Flea, Tick & Mosquito Spray

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  • Usage: Treatment
  • Lifestage: Adult
  • Formulation: spray

Wondercide has produced a spray to assist you combat fleas and ticks if you’re seeking for a natural alternative therapy.

This product includes chemicals that are restricted in some states; therefore, residents of Maine, Indiana, New Mexico, North Dakota, and South Dakota cannot purchase it.

This product’s active components include lemongrass and cedarwood oil. To kill fleas and ticks, it may be sprayed directly on your dog or on household goods like furniture.

While this product is available in other fragrances, we do not suggest the peppermint. It contains peppermint essential oil, which is hazardous to canines and felines if ingested.

As the spray includes 1.5% lemongrass oil, which can induce stomach discomfort in dogs and cats, care should be taken to avoid ingestion. Due to its contents, this spray must be administered to your dog’s entire body on a frequent basis for it to be effective.


  • Mostly vegetable ingredients
  • Also applicable on domestic surfaces


  • Not accessible in all areas
  • Must be used regularly
  • Peppermint may be poisonous

The shampoo Adams Plus Flea & Tick

Adams Plus Flea & Tick Shampoo

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  • Usage: Treatment
  • Lifestage: Adult, elderly
  • Formulation: shampoo

If prevention has failed and your dog is already plagued with fleas, Adams Plus Flea and Tick Shampoo  should be your next line of defense. This shampoo will clean your dog while killing fleas and ticks on contact.

Due to the presence of lanolin, coconut extract, and oatmeal, this product is ideal for sensitive skin. It just need a tiny bit to be effective, thus the bottle should last a long time.

This shampoo kills and prevents fleas for 28 days, however it is intended primarily for the treatment of an existing infestation.

After eliminating the infestation, more preventative measures must be implemented, otherwise you will need to bathe your dog often.


  • Gentle formula for sensitive skin
  • Smells good
  • Eradicating flea infestations


  • Toxic if consumed
  • Requires regular reapplication

Dog Seresto Flea and Tick Collar

Seresto Large Dog Vet-Recommended Flea & Tick Treatment

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  • Usage: Prevention
  • Age: puppy and adult
  • Product shape is a collar

For certain pet owners, particularly those who reside in tick-infested areas, a collar may be the most effective method of protection.

It can be taken with other flea and tick preventatives; however, this should be properly addressed with your veterinarian prior to mixing medications. Seresto collars  are cost-effective choices that kill fleas and ticks on your dog for up to eight months.

It is waterproof and available in two sizes. In contrast to other flea collars, this one is non-greasy and odorless, so you can feel comfortable keeping it on your dog.

The most problematic aspect of flea collars is their design. The collar is meant to break apart for your dog’s protection. This is essential because if your dog becomes entangled in the leash, you need it to break free rather than suffocate him.

This safety feature implies that the majority of dogs will not wear the collar for long. Additionally, it cannot be reattached, therefore you are need to use a new collar every time.


  • Additional protection for endemic regions
  • Functional for up to 8 months
  • Odorless and greasy-free


  • Breakaway design makes it difficult to retain hold

Dogs’ Frontline Shield

FRONTLINE Shield Flea & Tick Treatment

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  • Treatment and preventive measures
  • Lifestage: Adult
  • Product Form: Liquid

Frontline Shield is a topical medication that helps repel fleas, ticks, and mosquitoes. It is effective for all phases of life and must be reapplied every 30 days. The material is waterproof after 24 hours.

The parasiticide contained in this product is subject to California warnings. N-methylpyrrolidone is a chemical that, according to the state, causes birth abnormalities or reproductive damage.

This product performs less effectively than many others on this list. Flea control may take numerous administrations, especially for dogs with thick coats.

If your dog already has a flea infestation, there are more effective treatments available. It appears to be effective at repelling insects, though.


  • Excellent preventative
  • Also repels mosquitos


  • Includes health cautions
  • Flea prevention is superior to therapy

How to Choose the Most Effective Topical Flea and Tick Treatments for Dogs

What to Look for in Products to Prevent Fleas and Ticks

Transport method

There are a variety of flea and tick preventive product distribution options. In these studies, we only addressed topical techniques, such as drinks, shampoos, and collars, but there are also oral products available. Oral products have the benefit of being eaten, so you do not have to worry about your dog being wet or the treatment being removed by water. However, oral medications are sometimes more expensive than topical medications.

The Ingredients Used

The majority of topical flea and tick prevention medicines contain a pesticide. It is essential to investigate the particular compounds in each product to identify which insects it kills and whether it is suitable for use near animals and children. Discuss with your veterinarian which chemicals are best for your scenario, since certain substances carry a greater chance of triggering an unfavorable response in your dog. They will have a thorough understanding of the local insects and those that pose a threat to your dog. Not all regions contain mosquitoes that transmit heartworms, so you may not need to expose your dog to additional chemicals to prevent them.


Different products function for varying lengths of time. Some require weekly or monthly use, while others are effective for several months. This will determine not only how frequently you must administer the medicine, but also how much you must pay.

How Do You Detect Fleas on Your Dog?

There are several obvious indications that your dog has fleas:

  • There is itching.
  • They are biting themselves so much that they are shedding fur.
  • There are insects on their skin.
  • Small black specks, known as “flea dirt,” are visible on your dog’s skin.

How Can Fleas Be Prevented?

In addition to flea and tick treatments, there are a few things you can do to prevent your dog from acquiring fleas. Fleas inhabit shaded outdoor locations, sand, leaves, and other trash heaps. Keeping your lawn short and preventing your dog from playing in leaf heaps might limit the likelihood that your pets will be exposed to these insects.


TevraPet FirstAct Plus Flea and Tick Spot Treatment for Dogs is the most cost-effective topical flea and tick treatment for dogs. It is also excellent at preventing parasites in dogs and is inexpensive.

Using the characteristics of the flea and tick treatments provided in our buyer’s guide can assist you in understanding what to look for the next time you search for flea and tick treatments. His dog has ticks.

BestForPets (bestforpets.org) would like to thank our readers for visiting our website to learn about the best topical flea and tick treatments for dogs. We hope that you have selected an effective flea and tick treatment for your pet.

Author Image

Dr. Deborah Fletcher

Deborah R. Fletcher, DVM, is a skilled veterinarian with more than 15 years of experience dealing with companion and exotic animals. She has experience caring for a variety of animals, including household cats and dogs, reptiles, birds of prey, and even primates. Dr. Fletcher is a valuable part of the BestForPets team, where she contributes to their aim of providing pets and their owners with the finest possible treatment and services.

Veterinarian (DVM) Dr. Deborah Fletcher


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