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The 8 Best Rat & Mouse Urine Cleaners

Rat and mouse urine can be difficult to eliminate. Pee includes ammonia, which can cause a variety of health difficulties, including asthma and other respiratory problems; thus, it is essential to clean the urine immediately to prevent any long-term harm.

Fortunately, a variety of treatments are available for cleaning rat and mouse urine. In this post, BestForPets (bestforpets.org) will analyze the best rat & mouse urine cleaners and provide an overview of what to anticipate from each product. It might be tough to clean up rat and mouse pee, but with the correct solution, it can be done fast and simply. Therefore, without further ado, let's begin!


Spray Hepper Advanced Bio-Enzyme Pet Stain & Odor Remover

The Hepper Advanced Bio-Enzyme Pet Stain & Odor Eliminator Spray is the finest rat and mouse urine cleaning overall. This solution is suitable for use on carpets, hard surfaces, furniture, and a variety of textiles. It utilizes enzymes to bind to, lift, and eliminate smells and stains, including set-in stains, in addition to cleaning urine.

It has a neutral aroma that will not overpower your room and will not only mask urine scents. It should also have no effect on the delicate respiratory systems of cats, dogs, and rodents. It is effective on stains and smells caused by feces, vomit, drool, and food, in addition to pee.

Due to its effectiveness, the 32-ounce bottle will last a long time. In addition, Hepper sells this product with a satisfaction guarantee of one hundred percent. As with the majority of enzymatic cleaners, this product may cause certain textiles to lose their color. Test it in an inconspicuous spot before using it.

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  • Multiple floors, furniture, and fabric kinds are compatible.
  • Enzymes are used to remove stains and smells.
  • The neutral aroma that is not overpowering.
  • Large bottle capacity
  • 100 percent satisfaction assured


  • May remove the color from some materials.


Urine Gone Stain & Odor Remover for Pets

Urine Gone Pet Stain & Odor Eliminator is an enzyme-based product that breaks down smells and eliminates stains by penetrating deeply into fibers. This odor neutralizer may be used on carpets, wood, tiles, bathrooms, sofas, mattresses, and even cages. It is absolutely non-toxic, so you may use it on rat and mouse messes as well as other pet mishaps.

This solution contains enzymes that eliminate smells and stains at their source. It immediately enters the fabric’s fibers to eliminate smells and stains. This solution is substantially less expensive than many of our other top-rated products and is the most cost-effective rat and mouse urine cleanup.


  • Enzymes aid in removing odors and stains at their source.
  • Intensively permeates substance fibers
  • Functions on all surfaces
  • Eliminates urine odor rather than masking it.
  • Safe for both humans and rats


  • Some individuals dislike the aroma of the new formulation.


Simple Solution Pet Urine Destroyer

Simple Solution Pet Pee Destroyer eliminates urine stains caused by your rodent companion. This pet pee odor remover contains enzymes that eradicate the source of stubborn urine stains and discourage further incidents. It may be used on carpets, furniture, beds, fabric toys, clothes, and other water-resistant surfaces in your house.

This pet pee odor remover is designed not to damage colorfast carpets and includes an easy-pour lid for refilling sprayer bottles. It is authorized by the Carpet & Rug Institute for usage around rodents when applied as instructed.


  • Removes the stench of rat and mouse urine
  • Carpet & Rug Institute accreditation
  • Formulated to avoid damaging colorfast carpets
  • Contains enzymes that aid in removing stubborn pee stains.
  • It may be applied on water-resistant surfaces.


  • It has an initially offensive odor that dissipates with time.
  • You must replenish your own spray bottle.


ECOS for Pets! Stain & Odor Eliminator

ECOS for Pets is ecologically friendly and effective in removing rat waste. It eliminates stains and odors using a specific solution created by plants to clean up everything your rat or mouse has left behind.

It is manufactured by the top brand of eco-friendly cleaning goods and contains powerful enzymes that remove stains and odors effectively and safely, regardless of whether your rodent has an accident or an upset stomach.

Due to the fact that it is non-toxic, your rat or mouse may run free immediately after cleaning, so a fast spritz will get you back to having fun.


  • Contains cleaning chemicals derived from plants
  • Performs effectively on excrement, pee, blood, and other biological messes.
  • Made in America using non-toxic components.
  • Safe for use on rugs, carpets, upholstery, and fabrics
  • ECOS is the market leader in green cleaning.


  • Works better on stains than scents.


Shout Pets Oxy Urine Eliminator for Carpet and Upholstery

With the Shout Pets Oxy Urine Destroyer for Carpeting & Upholstery, you can ensure that your carpets, textiles, and upholstery are thoroughly cleaned. The product’s pee-destroying ingredient targets and degrades urine on contact, penetrating deeply into the fabric layers to eradicate all stains and smells.

Designed with a specialized-strength, deep-cleaning action, it utilizes the force of oxygen to eliminate even the most stubborn urine stains and odors, such as long-standing, set-in stains.

Additionally, it is mild enough to preserve the fragrance and appearance of your clothing. Apply the mixture for deep cleaning to filthy areas, let it permeate, and allow it to dry before vacuuming.


  • Destroys stains and smells on contact
  • Not harmful to carpets and textiles
  • Eliminates odor-causing microorganisms
  • A composition with a clean aroma that is manufactured in the United States


  • Skin contact may produce an allergic response.


Skout’s Honor Outdoor Urine & Odor Destroyer Spray

With Skout’s Honor Outside Urine & Odor Destroyer Spray, you can maintain your house, business, or pet facility’s interior and outdoor areas in perfect shape.

Its potent mixture swiftly removes unpleasant odors from cages, floors, concrete, brick, artificial turf, outdoor furniture, and other areas where you and your rat or mouse spend time together. This eco-friendly cleaner is created in the United States, which is the greatest aspect.


  • United States manufactured
  • The formula degrades urine
  • Removes smells without difficulty
  • Thorough cleaning
  • Eco-friendly


  • Contact with the eyes is irritant.
  • Use only in a well-ventilated area


ZORBX Pet Urine Stain & Odor Remover

Utilize ZORBX Pet Urine Stain & Odor Remover if you need to clean up rat or mouse messes in your home immediately. With its potent natural enzyme mix, this cleanser removes urine smells and stains caused by rat urine.

You may use it on any surface, including carpets and furniture, in your rodent’s cage without issue. Even better, no mixing is necessary; it may be used directly from the bottle.


  • United States manufactured
  • It doesn’t simply cover smells
  • Secure and efficient
  • No mixing necessary
  • Compatible with carpets and upholstery


  • The treated area must be totally dried

Buyer's Guide

How Do You Remove Rat and Mouse Urine Odors?

Using an enzyme cleanser to eliminate the odor of rat or mouse urine is one option. These cleansers function by degrading the proteins in urine, which removes the odor. Using a combination of baking soda and water is another method for removing the odor. As a natural deodorizer, baking soda may help eliminate odors from urine as well as other odors.

The last alternative is to use a solution of vinegar and water or a solution of one part bleach to nine parts water to clean the area. You can also use one of the professional cleaners discussed above, which are intended to eliminate unpleasant scents.

Will Rat Urine Odor Disappear?

In general, rat urine odors do not vanish on their own. It is essential to clean the area where rat pee was left as quickly as possible to avoid the odor from worsening. If the stench is severe, employing a cleaning will assist in eliminating it.

Whether or whether a rat pee odor will dissipate depends on a variety of circumstances, such as the intensity of the odor and the type of surface it is on.

In certain instances, the odor of rat urine may diminish with time, and in others, it may grow more pervasive. Identifying and removing the cause of the rat urine odor is the most effective method for eliminating the stench.

What Does Rat And Mouse Urine Smell Like?

The urine of a mouse or rat has an ammonia-like odor. This is because their urine contains a high concentration of the ammonia-smelling chemical urea. The urine of other species, including humans, lacks this strong ammonia odor because they generate far less urea.

Can Rat Urine Cause Illness?

Concerning the possible health concerns linked with rat urine, there is a considerable lot of doubt. Some studies believe that rat urine may include pathogenic germs and poisons that may make a person ill if exposed to it.

To establish the possible risks of rat urine, further study is required. Until further notice, it is usually better to avoid contact with rat urine if at all feasible.

How Can One Prevent Pet Rats From Urinating Everywhere?

Training your rat to use the toilet will prevent it from defecating everywhere. However, if your rat is urinating in modest amounts, this is typical behavior. If there is a problem, there are several solutions.

You must first comprehend the distinction between peeing and marking. Based on the rationale for their actions, pet rats can be trained to have better elimination habits.

What is the distinction between Urinating and Marking?

To discover the reason for your pet’s urinating outside of its cage, you must differentiate between peeing, puddles, and drops. The activities of urinating and marking are distinct, yet interrelated, and are driven by distinct factors.

When a rat is in discomfort, afraid, or has begun urinating in unsuitable areas, there are more puddles. As rats use droplets to identify their environment, droplets are a typical occurrence.

Why Does My Rat Urinate All Over?

A pee puddle on the floor or urine-soaked sheets would make anyone upset. Keep in mind, though, that the pet rat who left the mess may have been ill. Rats often do not leave enormous puddles unless they have a full bladder after a lengthy snooze.

Significant amounts of pee suggest that the pet rat was scared or even in pain at the time of the mishap. Ensure that you console your pet rat if this occurs. Putting them back in their cages or giving them safe areas is typically a good option, and identifying and removing the source of their anxiety will reduce future spills.

Why Does My Rat Urinate Throughout the House?

The rat is most likely scent marking, a form of communication with other rats. Rats utilize urine and other fluids to mark their territory, identify friends and adversaries, and communicate sexual desire signals. Typically, males will mark more frequently than females. Additionally, you may observe rats licking or gnawing on items to disseminate their scent.

How Can I Reduce the Urinating and Marking Behaviors of My Pet Rat?

There are a few things that rat owners may take to lessen the peeing and marking activities of their pet rats. One is to maintain the rat’s living environment clean, odor-free, and filled with toys and hiding places. Additionally, owners might attempt to educate their rats to use a litter box, which can lessen urine marking behavior.

How Do I Housebreak a Pet Rat?

There are several methods for housebreaking a pet rat. One method is to install a litter box and bedding in the corner of the rat’s cage. Once rats become used to the box, they will often utilize it.

Placing some bedding in a small container and placing it near where the rat spends most of its time is another method for litter training rats. Eventually, the rat will use the bedding as a restroom.


In conclusion, rat and mouse urine cleaners are an efficient and inexpensive method for removing pee from a variety of surfaces. Even non-porous surfaces can absorb odors, therefore it is important to clean up any mishaps as soon as possible. Particularly, delicate furniture requires early care. Once urine has soaked into them, it might be difficult to remove the odor and discoloration. Be sure to follow the instructions on the bottle for the best results.

Urine Gone Pet Stain & Odor Eliminator is an excellent alternative to Hepper Advanced Bio-Enzyme Pet Stain & Odor Eliminator Spray if you’re on a tighter budget.

We honestly appreciate your time in reading thus far. BestForPets (bestforpets.org) believes this article will assist you in selecting the best rat & mouse urine cleaners for your needs

Author Image

Dr. Deborah Fletcher

Deborah R. Fletcher, DVM, is a skilled veterinarian with more than 15 years of experience dealing with companion and exotic animals. She has experience caring for a variety of animals, including household cats and dogs, reptiles, birds of prey, and even primates. Dr. Fletcher is a valuable part of the BestForPets team, where she contributes to their aim of providing pets and their owners with the finest possible treatment and services.

Veterinarian (DVM) Dr. Deborah Fletcher


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