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The 11 Best Puppy Flea & Tick Medicines

Nothing is more joyful than taking a new puppy home! The first year of your puppy's life is perhaps one of the most crucial since it establishes the foundation for a long, healthy, and happy life. They should get enough (but not too much) exercise, eat the best food for their quickly growing bodies, and, most importantly, avoid getting parasites.

Once a flea infection takes root, it can be difficult to eradicate, and fleas can irritate your dog's skin indefinitely. Even scarier is the fact that ticks can carry diseases that could kill both your dog and you and your family.

This is why tick and flea prevention for your developing puppy is essential. Choosing a medication that is both safe for young pups and effective against these parasites may be a difficult and stressful process.

Fortunately, you've found the correct location! BestForPets (bestforpets.org) has compiled a list of the best puppy flea & tick medicines, along with in-depth evaluations, to assist you in selecting the best alternative for your new puppy. Let's get started!


TevraPet Activate Flea & Tick Protection for Dogs



Although it has the same active components as K9 Advantix II, the TevraPet Activate II flea and tick prevention drops did not function as well.

Because it was not as effective as the Bayer product, it appears that it may not have the same quantities of these components.

Of course, it is also far less expensive, so we did not anticipate the same degree of performance. It did have a good impact, but it was not as obvious as we would have liked.

The inexpensive price includes a four-month supply. This is one of the better deals, but the decreased efficacy is a compromise that we would like to avoid.

Worse, some of our dogs had an unpleasant reaction to these drops and appeared to loathe them after application. After administering the drops, our worried dog began to whine continuously.

After observing this reaction, we were hesitant to provide this product to our other pets. However, we had previously used medication on several dogs without bad effects, and it was only partially successful on them.


  • Reasonably priced
  • 4-month provision
  • Kills and repels


  • Some dogs reacted poorly
  • Was less efficient at killing fleas


ZoGuard Dog Flea and Tick Spot Treatment



  • Three months of distribution
  • Minimum Age: 8 weeks
  • Topical formulation
  • Frequency: Monthly

ZoGuard Flea & Tick Spot Treatment for Dogs is the most cost-effective flea and tick medication. This topical formulation comprises Fipronil (9.8%) and (S)-methoprene (8.2%), both of which have been demonstrated to prevent and kill fleas, flea eggs and larvae, chewing lice, and ticks on contact.

Additionally, it helps prevent the mites that cause sarcoptic mange. It begins working immediately, lasts up to a month, and is waterproof, keeping your dog secure even when they are wet.

Multiple consumers stated that this recipe initially worked, but only for a week or two.


  • Inexpensive
  • Contains tried and true components
  • Contact-kills fleas and ticks
  • Aids in the prevention of sarcoptic mange-causing mites
  • Waterproof


  • Not long-lasting


Seresto Tick and Flea Collar



  • Imidacloprid and Flumethrin are their generic names
  • Form of Administration: Collar

Try the Seresto Flea & Tick Collar if you desire long-term protection from fleas and ticks without the burden of remembering to give your dog medication on a regular basis.

It is odorless and non-greasy, and features a quick-release safety function in case your dog becomes entangled. Even with frequent swimming or bathing, the drug is effective for up to eight months, making it suitable for protracted tick seasons.

The most significant disadvantage of wearing a flea-and-tick collar is whether or not your dog will wear it. The quick-release buckle is effective, perhaps too effective.

It will detach with the slightest snag. Once it snaps, the collar cannot be reapplied and a replacement must be purchased.


  • Provides eight months of protection against fleas and ticks
  • Simple to employ
  • Odorless and greasy-free
  • Safe for pups older than 7 weeks


  • It can be difficult to adapt
  • Some canines do not wear their collars


Capstar Oral Flea Treatment for Dogs – Most Effective for Puppies



  • Supply: 6 tablets
  • Minimum Age: 4 weeks/ 2 pounds
  • Form: Tablet
  • Frequency: One per day maximum

The Capstar Oral Flea Treatment for Dogs is fast-acting, beginning to work within 30 minutes, and killing 90% of fleas within 4 hours. The tablets include nitenpyram, which is effective and safe for both people and pups as young as 4 weeks.

Capstar states that a single dose should be sufficient, although it can be used daily if fleas return. The remaining tablets may be preserved and will retain their efficacy, and you can give your dog a pill once every month to avoid reinfestation.

This treatment is efficient against fleas but ineffective against ticks and other parasites. Additionally, it does not destroy all flea life stages, so you will likely need to reapply, which may be both irritating and costly.


  • Starts functioning within 30 minutes
  • 90% successful after 4 hours
  • Compatible with pups as early as 4 weeks
  • Also effective as a preventive


  • Lacking efficacy against ticks and other parasites
  • Does not destroy all phases of flea life


Small Dog Frontline Plus Flea & Tick Spot Treatment



  • Three months of distribution
  • Minimum Age: 8 weeks
  • Topical formulation
  • Frequency: every four weeks

Pet owners have relied on Frontline for tick and flea control for years, and with good reason. Frontline Plus Spot Treatment is very effective against adult fleas, flea eggs, flea larvae, chewing lice, and ticks, and is prepared with fipronil and (S)-methoprene.

The solution is fast-acting, durable for up to thirty days, and entirely waterproof after twenty-four hours.

Although Frontline is one of the most reputable brands for flea and tick control, it is a pricey product. In addition, several consumers stated that the solution irritated the application site, causing itching and redness.


  • A reputable brand in flea and tick protection
  • Kills fleas, flea eggs, flea larvae, ticks, and chewing lice
  • Fipronil and (S)-methoprene are present
  • Suitable for pups older than 8 weeks
  • Waterproof


  • Expensive
  • Possible skin irritant for certain dogs


Dog K9 Advantix II Flea and Tick Spot Treatment



  • Six months’ supply
  • Minimum Age: 7 weeks/4 pounds
  • Topical formulation
  • Frequency: Monthly

K9 Advantix II Spot Treatment is a veterinarian-recommended, broad-spectrum treatment developed to repel and kill fleas, ticks, and mosquitoes on contact. The treatment is 100% waterproof and effective for up to four weeks against all stages of fleas, lice, and biting flies.

The recipe comprises imidacloprid, permethrin, and pyriproxyfen, which are proven to prevent flea and tick infestations, and begins acting within 12 hours.

Multiple buyers stated that this product irritated their dog’s application site, resulting in chronic itching for several days.


  • Vet suggested
  • Effective against ticks, fleas, mosquitoes, and lice
  • 100% waterproof
  • Starts functioning within 12 hours


  • Expensive
  • Resulted in cutaneous inflammation in some canines


Dog Flea and Tick Spot Treatment with Vectra



  • Three months of distribution
  • Minimum Age: 8 weeks
  • Topical formulation
  • Frequency: Monthly

Vectra Flea & Tick Spot Treatment repels and kills fleas, mosquitoes, biting sand flies, mites (excluding mange mites), and ticks, such as brown dog ticks, American dog ticks, deer ticks, gulf coast ticks, and lone star ticks.

The waterproof product is quick-drying, fast-acting, and begins working within minutes after application; it may be used on pups as young as eight weeks old. It includes the proven flea and tick protection chemicals dinotefuran, pyriproxyfen, and permethrin.

A few customers stated that this product did not work at all on their puppies or only worked for a week or so, and that fleas and ticks returned after a week or two. Additionally, it caused skin irritation at the application site in several dogs.


  • Eliminates fleas, ticks, and other parasites
  • Rapidly drying and acting
  • Waterproof
  • Available for use on pups beginning as 8 weeks of age


  • Not necessarily effective on all dogs
  • Short term of effectiveness
  • Possible skin irritation

Buyer's Guide: Selecting the Finest Flea and Tick Medication for Puppies

After bringing your new puppy home, there are numerous critical issues to consider, including immunizations, training, socialization, and flea and tick control.

Most flea and tick treatments on the market are only safe for puppies at about 8 weeks of age, so now is the ideal time to begin preventative care, especially if you live in an area where ticks and fleas are common.

On the market are several flea and tick preventatives, most frequently shampoos, sprays, collars, chewable pills, and spot treatments.

Although collars have some influence on dogs, spot treatments and tablets are the most popular and, perhaps, most effective items, particularly for pups.

Chewable tablets are simple to give because they are typically sweetened to encourage your dog to consume them, however spot treatments might be difficult to apply to an active dog!

Puppies are at a critical developmental stage, so you’ll want to avoid flea and tick infestations, but you’ll also want the medication you employ to be as safe as possible. Consider the following factors when selecting flea and tick medication for your dog.

Are Treatments for Fleas and Ticks Safe for Puppies?

As long as you adhere to the manufacturer’s suggested age and weight limitations, it is absolutely safe to administer flea and tick treatments on pups. Obviously, each dog is unique, and some may experience bad responses to specific treatments.

These adverse effects often appear between 1 and 12 hours after administration and vary according on the medicine type. Typical adverse effects include:

  • Itching
  • Tremors
  • Excessive salivation
  • Lethargy
  • Diarrhea

If you observe any bad effects in your dog, call your veterinarian immediately. After using a spot treatment, it is advisable to wash the affected region with mild soap and warm water.

However, most dogs recover quickly and readily from unfavorable responses, and the majority of dogs do not have reactions.

Many of these responses result from not following label instructions; thus, it is crucial to read the instructions carefully, avoid giving the drug too frequently, and ensure that the dosage is appropriate for your dog’s age and weight.

Are Flea and Tick Treatments Necessary?

Fleas and ticks are not only unpleasant for your dog, but they can also cause serious diseases. Fleas are one of the major causes of tapeworm because they transmit the parasite’s larvae to your dog and cause skin allergies and irritation.

Lyme disease, Rocky Mountain spotted fever, ehrlichiosis, and anaplasmosis are among the disorders transmitted by ticks.

Flea and tick treatment can go a long way toward avoiding these diseases, but you must also treat your house to stop the flea life cycle. Always inspect your dog for fleas and ticks after walks, and remove any adhering ticks with care.

In most situations, ticks must remain attached for 36-48 hours or longer in order to spread disease; nevertheless, the sooner you remove them, the better.


Veterinarians recommend TevraPet Activated Flea and Tick Prevention for Dogs, which is also our top pick for flea and tick prevention in general.

ZoGuard Flea & Tick Spot Treatment for Dogs is the most cost-effective tick and flea treatment available. This topical product combines chemicals proven to prevent and kill fleas, flea eggs and larvae, lice, and ticks on contact. It has a one-month shelf life and is completely waterproof.

Bringing a new puppy home may be stressful, and protecting it from fleas and ticks can add to that stress. Fortunately, there are proven remedies, and we hope that our in-depth evaluations have helped you select the most effective tick and flea medication for your dog. me. My newborn baby!

BestForPets (bestforpets.org) would like to thank our readers for visiting our website to learn about the best puppy flea & tick medicines. We hope that you choose the appropriate tick and flea treatment for your dog.

Author Image

Dr. Deborah Fletcher

Deborah R. Fletcher, DVM, is a skilled veterinarian with more than 15 years of experience dealing with companion and exotic animals. She has experience caring for a variety of animals, including household cats and dogs, reptiles, birds of prey, and even primates. Dr. Fletcher is a valuable part of the BestForPets team, where she contributes to their aim of providing pets and their owners with the finest possible treatment and services.

Veterinarian (DVM) Dr. Deborah Fletcher


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