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7 Best Oral Flea Treatments For Cats In 2024

Welcome to our guide on the "Best Oral Flea Treatments For Cats" that can be a huge problem for cats, causing discomfort and even spreading diseases. That's why it's crucial to find an effective flea treatment that can kill fleas and prevent their eggs from developing.

Oral flea treatments are a popular and easy-to-use method of flea control. They come in the form of tablets, chewables, or liquids that you give to your cat by mouth. However, not all oral flea treatments are created equal, and some may not be suitable for your cat.

That's why BestForPets has researched and reviewed the best oral flea treatments for cats based on their ingredients, safety, and effectiveness. Our recommendations will help you choose the right oral flea treatment for your cat and keep them flea-free.

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Deborah R. Fletcher (DVM)


The information provided is current and up-to-date, in line with the latest research conducted in the field of veterinary medicine.

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1 Capstar Fast-Acting Oral Flea Treatment for Cats Capstar Fast-Acting Oral Flea Treatment for Cats View on Amazon
2 CAPACTION Fast-Acting Oral Cat Flea Treatment CAPACTION Fast-Acting Oral Cat Flea Treatment View on Amazon
3 Natural Flea & Tick Supplement Flea Away Natural Flea & Tick Supplement Flea Away View on Amazon
4 TevraPet Flea Prevention for Cats TevraPet Flea Prevention for Cats View on Amazon
5 Natural Pet Supplies Food Supplement for Fleas Natural Pet Supplies Food Supplement for Fleas View on Amazon
6 Frontline Plus Frontline Plus View on Amazon
7 Dog & Cat MD QuickTabs Nitenpyram Flea Pills for Cats Dog & Cat MD QuickTabs Nitenpyram Flea Pills for Cats View on Amazon

What are oral flea treatments for cats and How do they work?

Oral flea treatments are medications that you give to your cat by mouth, as a tablet, chewable, or liquid. They contain active ingredients that kill adult fleas and prevent their eggs and larvae from developing.

Depending on the type of active ingredient, oral flea treatments can work in different ways. Some can eliminate adult fleas within hours of ingestion, while others can prevent the development and maturation of flea eggs and larvae. Some are also effective against parasites.

Here are some common ingredients found in oral flea treatments for cats:

  • Spinosad: a naturally occurring substance derived from soil microorganisms that causes adult fleas to convulse and die. It also destroys flea eggs and larvae by preventing their development.
  • Nitenpyram: a synthetic compound that kills adult fleas by interfering with their nerve signals, leading to their death. It does not affect flea eggs or larvae.
  • Lufenuron: a synthetic compound that prevents the development of flea eggs and larvae by inhibiting the production of chitin, which makes up their exoskeleton. It has no effect on adult fleas.
  • Lotilaner: a synthetic compound that kills fleas and parasites by interfering with their nervous system, leading to their death. It also prevents the development of flea eggs and larvae.


1. Capstar Fast-Acting Oral Flea Treatment for Cats

CAPSTAR (nitenpyram) Oral Flea Treatment for Cats

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Capstar is an oral flea treatment that is highly effective for cats, beginning to eradicate fleas within just 30 minutes of administration.

It is safe for cats and kittens over one month of age and is available without a prescription. The active ingredient in Capstar is nitenpyram, which is ingested by fleas when they bite your cat and enters the bloodstream.

This product is designed to quickly eradicate flea infestations, and as the medication starts to work, fleas will begin to fall off your cat. Capstar can also prevent re-infestations, and daily dosing is permitted.

It is important to note that your cat may appear to scratch itself more frequently while using Capstar. However, this is not an adverse effect of the medication but rather a temporary reaction to the destruction of the fleas.

Capstar has undergone quality evaluation and is recommended by veterinarians. It is available in packs of six doses for cats weighing between 2 and 25 pounds.

This flea medication is an excellent choice for cat owners seeking a fast-acting and effective treatment for flea infestations.


Flea treatment that works quickly

Everyday use is safe.

If fleas reappear, this treatment can be used.


Scratching becomes more intense.

Fleas die in the environment.

2. CAPACTION Fast-Acting Oral Cat Flea Treatment

PetArmor CAPACTION (nitenpyram) Oral Flea Treatment for Cats

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CapAction is an oral flea medication that contains nitenpyram as its active ingredient.

It is a fast-acting medication that can start killing fleas in just 30 minutes after being administered. This medication is safe for adult cats and kittens over four weeks of age, weighing between 2-25 lbs.

CapAction does not require a prescription from a veterinarian and is easy to administer orally, without any mess or rubbing off.

CapAction is an effective treatment for flea infestations, as it can quickly kill adult fleas that may cause allergy dermatitis. This medication is also safe for pregnant and nursing cats.

It comes in a pack of six doses, and if your cat gets re-infested with fleas, you can safely give them another dose as often as once a day.

This flea treatment can help reduce itching and shedding in cats and is a cost-effective option compared to other nitenpyram flea treatments.

Overall, CapAction is a safe and efficient oral flea medication that can quickly kill fleas and prevent re-infestations.

It is an easy-to-use and cost-effective option for cat owners looking for an alternative to topical flea treatments.


Flea removal that works


Fleas are killed within 30 minutes.


Suitable for tiny to medium-sized cats

3. Natural Flea & Tick Supplement Flea Away

Flea Away All Natural Supplement for Fleas

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Flea Away  is an all-natural vitamin complex that provides a safe and effective barrier against fleas, parasites, and mosquitoes.

It comes in a package containing 200 chewable liver-flavored tablets, making it an exceptional value.

Unlike other flea treatments, Flea Away does not use pesticides or hazardous chemicals. Instead, it is formulated in accordance with FDA guidelines to ensure its safety for cats, including lactating cats and their kittens.

In addition to repelling fleas and ticks, the vitamin complex in Flea Away promotes healthier skin, reduces shedding, enhances coat sheen, and supports joint health in cats.

By naturally repelling fleas, Flea Away can also help prevent allergic reactions in cats caused by flea bites.

It is recommended to give Flea Away to your cat daily, as it takes approximately 20 to 30 days for the supplement to build up in your cat’s system and provide adequate protection.

While this natural flea treatment may take longer to be effective than other oral flea treatments, it is a safe and effective alternative that can be used indefinitely.

Flea Away is sourced and manufactured in the United States to ensure its effectiveness and quality.

With its all-natural ingredients and lack of harmful chemicals, Flea Away is an excellent choice for cat owners seeking a safe and effective natural flea treatment for their pets.


Flea prevention and treatment


Ticks and mosquitos are also targeted.



4. TevraPet Flea Prevention for Cats

TevraPet FirstAct Plus Flea and Tick Prevention for Cats

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The TevraPet  flea preventative for cats contains potent and effective constituents, such as Fipronil and (S)-Methoprene, in a fast-acting formula.

Helping your cat eliminate parasites and fleas permanently not only eliminates the infestation but also prevents further infestations.

This is due to the fact that it effectively eliminates all insects, larvae, and eggs, including those that can transmit Lyme disease.

This formula is not only fast-acting, but also very simple to use. Simply pour the formula onto your cat’s neck using the included mess-free applicator.

Featuring a six month supply, six applicators, and six months of flea prevention doses, this product is manufactured in a certified Eu-GMP facility and quality-tested by a third party.

TevraPet flea preventative for cats is comparable to Frontline Plus for Cats. It contains Fipronil and (S)-Methoprene, which are the same fast-acting, vet-quality active ingredients found in the leading brand.

This product can break flea life cycles, stop infestations, and prevent new ones. It repels and kills fleas and ticks on contact, and it kills flea eggs and larvae, chewing lice, and all stages of ticks, including those that may transmit Lyme disease.

This product is a powerful and affordable flea protection solution. Your cat can be protected from tip to tail for 30 days with each easy-to-apply application.

It includes six topical doses of flea and tick prevention, and you can apply these flea drops to the base of your cat’s neck once every 30 days.

Results are guaranteed with TevraPet flea preventative for cats. It is made in Germany in a certified Eu-GMP facility and tested to meet rigorous standards of quality and consistency.


Leaves no sticky mess or unpleasant odor

Scientifically-backed ingredient

Kills fleas from all life stages


Applicator design can be improved

5. Natural Pet Supplies Food Supplement for Fleas

Flea-Free Pure Organic Food Supplement and Natural Pet Products

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Natural Pet Supplies Food Supplement for Fleas  is a liquid-based flea supplement for cats and dogs that contains allicin, an active component derived from dried garlic.

This product is effective in treating and preventing flea infestations in pets. Garlic has enzymes and nutrients that can significantly reduce flea toxicity and repel them from biting or remaining on your pet.

The supplement can be added to your pet’s food or water and is safe for regular use. However, it may take a few weeks for the dosage to accumulate in your pet’s digestive system before you see results.

While it is less expensive than tablet treatments, some pets may dislike the pungent flavor of this flea treatment liquid.

This product contains 200 vitamins and minerals from its chemical-free ingredients, including citrus and herbs that supply Vitamin C, complex carbohydrates, and antioxidants.

Its pet-safe ingredients include garlic, ginger, and vinegar, which help with digestion and ensure that the supplement can enter your pet’s system.

It can effectively work on all blood-feeding insects, including biting flies, fleas, lice, mites, mosquitoes, and ticks. Garlic, the major ingredient, detoxifies and goes into your pet’s blood, emitting enzymes that prohibit female insects from laying eggs.

It is suitable for various pets, including birds, ferrets, hamsters, rabbits, guinea pigs, and even reptiles. It can be used for young and old pets, and it is safe for nursing pets.

Many consumers describe this product as inexpensive yet effective, as it works in miracles in driving parasites away.

It is an all-in-one product that can replace the need for multiple products for parasite protection. Try it for yourself and see its benefits.


Flea treatment that is holistic

Flea bites and eggs are avoided.

Simple to administer


Oral pills are more effective.


6. Frontline Plus

FRONTLINE Plus Flea and Tick Treatment

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Frontline Plus  is a highly effective flea treatment for cats that also eliminates parasites and insects that feed on the animal’s blood.

For over two decades, pet owners have relied on this product, which provides a full month of protection with just one application. Even if parasites do not harm your cat, Frontline Plus will kill them upon contact.

The two active ingredients, fipronil and S-methoprene, work together to eliminate parasites and disrupt the flea life cycle in Frontline Plus.

S-methoprene prevents the development of flea eggs, larvae, and pupae, while fipronil kills fleas and parasites in their adult stages. However, it may take some time to eradicate all fleas, particularly in severe infestations.

Applying this flea and tick treatment for pets is simple. Apply the entire tube’s contents between your cat’s shoulder blades. The liquid medication is absorbed by the oil glands of the cat and self-distributes continuously throughout the month to the hair follicles.

Frontline Plus is an approved waterproof flea and tick treatment for cats and kittens weighing at least 1.5 pounds. It eliminates flea adults, flea larvae, parasites, and ticks, including those that can transmit Lyme disease.

This product not only eliminates existing infestations but also prevents new ones from forming, thus disrupting the flea life cycle.

Veterinarians have relied on Frontline Plus for nearly two decades, and it contains two potent insecticides, fipronil and S-methoprene.

This combination provides fast-acting, long-lasting protection for cats and kittens older than 8 weeks.

The long-lasting formula of Frontline is retained in the oil glands of the cat’s skin, providing 30 days of continuous protection against fleas and ticks. A three-month supply of three doses is available.

It is important to note that Frontline Plus does not prevent or eliminate worms, so you will need to use a different product to deworm your cat.


Kills five types of parasites

Fleas don’t have to bite for it to work


Not recommended for kittens younger than 8 weeks of age

Does not prevent worms

7. Dog & Cat MD QuickTabs Nitenpyram Flea Pills for Cats

Dog & Cat MD Maximum Defense QuickTabs Nitenpyram

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QuickTabs Nitenpyram Flea Treatment  is an alternative option for pet owners seeking a flea treatment containing nitenpyram.

This product is effective for both cats and dogs and comes in a package of six tablets. Unlike many other flea treatments on the market, these tablets are small and easy for your cat to swallow.

Additionally, they start working quickly, with effectiveness within 30 minutes after administration.

It is important to note that the tablets do not provide long-term relief. While flea treatments eliminate adult fleas almost instantly, they do not get rid of flea eggs or larvae, which means that your cat can easily become reinfested.

QuickTabs Nitenpyram Flea Treatment contains the same active ingredients as Capstar, but it may not be as effective in treating flea infestations on cats.

This tablet-form flea treatment is suitable for both cats and dogs. It is important to follow the instructions carefully to ensure that you administer the correct dosage to your pet.

As with any flea treatment, it is advisable to consult your veterinarian before administering this product to ensure its safety and suitability for your pet’s specific needs.


Kills adult fleas within 30 minutes

Small and easy to swallow

Contains 6 tablets


Doesn’t kill eggs or larvae

What are the benefits of oral flea treatments for cats?

1. Ease of administration

Oral flea treatments are simple to administer and do not require cleaning or topical application. You can give them to your cat in the form of a tablet, chewable, or liquid, either directly or mixed with food or a treat.

2. No chemical residues

Oral products are absorbed into your cat’s bloodstream and distributed throughout their body, unlike topical products, which can be rubbed off or rinsed away by grooming or bathing. Oral treatments leave no chemical residues that can irritate the skin or coat of your cat.

3. Uniform efficacy

Due to the length and density of your cat’s fur, topical products may not reach all skin areas or may be distributed unevenly.

Oral treatments are effective on all areas of your cat’s body and have uniform efficacy across the skin, which is not diminished by grooming or bathing.

4. Rapid and long-lasting relief

Some oral products can eliminate adult fleas within 30 minutes of ingestion and have a duration of up to one month. They can also reduce flea-related itching, scratching, biting, inflammation, and infections.

5. Protection from other parasites and diseases

Some oral products can also eliminate fleas and other parasites that pose a health risk to your cat. They can also prevent the transmission of diseases such as cat scratch fever and the plague from your cat to you.

What are the drawbacks of oral flea treatments for cats?

What are the drawbacks of oral flea treatments for cats?

1. Side effects

Oral flea treatments can cause side effects such as vomiting, diarrhea, and lethargy, or allergic reactions in some cats. While these side effects are rare, you should monitor your cat for any signs of discomfort or distress after giving them an oral product and contact your veterinarian if you notice any problems.

2. Unsuitability for certain cats

Oral flea treatments may not be suitable for kittens, pregnant or nursing cats, or cats with certain medical conditions or drug interactions.

Your veterinarian should be consulted before using any oral product on your cat to ensure that it is safe and effective for them.

3. Ineffectiveness against some fleas

Some oral products may not work well against certain species or strains of fleas that have developed resistance to the active ingredients.

In areas with high flea infestation or resistance, oral products may not be enough to control a severe flea infestation in your home or environment.

4. Prescription and dosing requirements

Some oral products are only available by prescription from a veterinarian, which may limit your access or increase your cost.

Additionally, some oral products need to be given to your cat every month or every few months to maintain their effectiveness, which may be inconvenient or difficult to remember.

Buyer's Guide

Which Flea Treatment Is Best For Your Cat?

When it comes to finding the best flea treatment for your cat, there are several options available. Let’s take a closer look at some of the most common ingredients found in flea treatments for cats.

1. Nitenpyram

Nitenpyram is an active chemical used in tablet flea treatments that reaches your cat’s bloodstream within a few minutes. Fleas will bite the cat and consume residues of the insecticide.

The fleas will eventually become immobilized and starve to death. However, one disadvantage of this active component is that it does not kill flea eggs.

2. Allicin

Allicin is produced by dried garlic and has strong anti-parasitic effects, making it a recommended natural flea treatment for both cats and dogs.

While it does not work as quickly as other pesticide flea treatments, it is quite effective at controlling, killing, and preventing fleas from attaching to your cat.

3. Niacin

Niacin is a Vitamin B derivative that repels fleas naturally. After a few weeks of oral administration, your cat’s body will have enough Niacin to reject and keep fleas from attracting to him.

4. Thiamine

Thiamine is a vitamin B1 derivative that can significantly reduce your cat’s chance of flea bites because fleas dislike the smell of Thiamine and the odor created by your cat’s pores repels them.

Buyer's Guide

Things to consider before buying Oral Flea Treatments for Cats

1. Effectiveness Against Additional Parasites

Flea tablets that can eliminate mites, lice, and other parasites in addition to fleas are the most suitable option for outdoor cats, as they are more susceptible to contracting various parasites.

However, if your cat’s only issue is with fleas, a more targeted formulation may be a better option.

2. Age of Treatment

Selecting flea medications for your cat requires considering its age. For instance, kittens aged three to twelve weeks are not recommended for flea medication, as overly potent treatments can be fatal for them.

Similarly, some parasite medications may be too strong for senior cats with preexisting health issues. Hence, it is recommended to consult with a veterinarian before administering any type of parasite medication to a kitten or cat.

3. Active Constituents

When selecting flea pills for your cat, it is crucial to examine the ingredients list to ensure that they do not contain anything harmful.

For example, flea products containing ingredients like pyrethrum are exceedingly toxic to cats and can lead to symptoms such as vomiting, diarrhea, drooling, muscle weakness, and trouble breathing.

It is recommended to purchase flea tablets from reputable brands that provide a complete list of ingredients on the label.

4. The Cat’s Weight

Your cat’s weight is an essential factor to consider when selecting effective parasite medications. Flea medications can be weight-dependent, and improper use of the treatment can be detrimental or fatal to your cat.

5. Number of Treated Parasites

Flea preventatives that also treat other parasites are optimal. The more parasites a preventative product protects against, the more effective it is.

Capstar is the only treatment approved for use in kittens younger than 8 weeks, and Frontline Plus, which addresses fleas, ticks, and lice, are the only exceptions to our recommendations.

6. Simplicity of Use

When comparing two similar products, the one with the simplest application may be the best option. For example, products that require the use of gloves to administer the treatment received lower rankings.

It is also essential to keep children and other animals separate from the treated animal for a certain period of time after administering the treatment.

Get expert tips for buying the best flea treatments for cats on BestForPets.org – keep your feline friend protected!


1. Is oral flea medication better than topical for cats?

Oral flea medication may be better than topical treatment for cats in some cases. It creates less mess and eliminates concerns over skin reactions to the active ingredients.

However, oral medications may cost more and prescriptions will need to be refilled regularly to maintain constant protection.

2. Are oral flea pills safe for cats?

Yes, all oral preventatives are available by veterinary prescription only, and some oral medications such as Capstar or Comfortis are both safe products for cats.

3. Is it safe to use topical and oral flea treatment together?

It can be safe to use the two medications together, but it’s usually not necessary. Always talk to your vet before using more than one flea medication. Some vets recommend alternating the doses between topical and oral medications in extreme cases.

4. Can I give my cat flea tablets every day?

In the case of a severe flea infestation, it may be necessary to treat the animals every day or every other day until the flea infestation is controlled.

Treatment may be resumed if fleas reappear. No more than one treatment should be given per day, and tablets should be given orally, with or without food.

5. Can fleas be transmitted from a cat?

Yes, fleas can be transmitted from a cat. As fleas can leap up to 13 inches, it is possible to acquire your pet’s fleas if you spend a lot of time around it.

Fleas do not remain on the human body for an extended period of time, but they can still produce short-term adverse effects such as itching and skin irritation.

6. Can bedbugs survive in litterboxes?

Bedbugs cannot survive in litterboxes. However, fleas can thrive in humid environments, so it is essential to clear your cat’s litter box every day to prevent flea infestations.

7. Can bedbugs infect animals kept indoors?

Fleas are less likely to infest cats that are kept indoors, but the likelihood of infestation increases if your cat escapes. It is important to take preventive measures to protect your cat from fleas, including regular flea treatments and keeping your home and yard clean.


The best overall product, the Capstar Fast-Acting Oral Flea Treatment for Cats , and the premium choice, the CAPACTION Fast-Acting Oral Flea Treatment for Cats , are two of BestForPetsbest oral flea treatments for cats.

These solutions have been shown to be the most effective against mild to severe flea infestations, allowing you to keep your cat comfortable and flea-free in just a few days.

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Dr. Freddie T. Young is a highly qualified veterinarian who specializes in emergency and critical care for tiny animals. Now, she serves as a relief veterinarian for various emergency and speciality hospitals, providing skilled treatment to animals in need.

Dr. Freddie Young


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