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The 15 Best Enzyme Cleaners For Dog Urine

If you have a dog who has urinated on the floor or the side of your sofa to mark their territory, you know how tough it can be to remove the urine and stench.

You may have cleansed the area, but your dog still urinates in that location.

Did you know that a dog's nose has 300 million odour receptors while ours only has 6 million?

So, even if humans think the odor is gone, the dog knows it's still there. That is why it is critical to choose an enzyme cleanser that can permanently remove the stink.

BestForPets (bestforpets.org) review list of the best enzyme cleaners for dog urine can help you decide which cleaner to use.

Our buyer's guide will provide you with suggestions and factors to keep in mind while purchasing a cleaner, allowing you to pick the ideal one for your needs.

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Deborah R. Fletcher (DVM)


The information provided is current and up-to-date, in line with the latest research conducted in the field of veterinary medicine.

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Best Overall: Hepper Advanced Bio-Enzyme Pet Stain & Odor Eliminator Spray

 Hepper Advanced Bio-Enzyme Pet Stain & Odor Eliminator Spray

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As much as we like our dogs, we must be prepared for terrible occurrences in which we must battle off their stains and odors. That’s where Hepper, with their Bio-Enzyme Pet Stain and Odor Eliminator, comes in as our top overall pick.

This spray not only removes stains and odors, but it is also safe to use on a number of surfaces, including carpets, hard floors, fabric, and furniture.

Hepper's Advanced Bio-Enzyme Pet Stain and Odor Eliminator comes in a 32-ounce bottle, so you get a lot of product for a low price.

This spray is not only excellent against your dog’s pee, but also against vomit, drool, and even feces—and it even works on cats!

Because it is scented neutrally, you won’t have to worry about the overpowering chemical odors that most stain and odor removers leave behind.

Another significant advantage? There is a 100% satisfaction guarantee, so if you don’t like it, you may get your money back.

Overall, we believe that the Hepper Advanced Bio-Enzyme Pet Stain & Odor Eliminator Spray is the greatest spray available today!


  • It is effective on both stains and strong smells
  • Excellent for a range of surfaces
  • 32-ounce bottle
  • Guaranteed 100% satisfaction


  • A little costly

OUT! Best Value for Advanced Stain and Odor Remover

 OUT! PetCare Advanced Stain and Odor Remover

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This is the finest enzyme cleaner for dog urine for the money since it contains three times the amount of pro-bacteria and enzymes and effectively removes pet stains and odor.

OUT! Advanced Stain and Odor Remover  may be used on any water-safe surface and is perfect for stains caused by urine, vomit, feces, and blood.

We appreciate that it can be used as a pre-wash in laundry and that it can be added to your carpet-cleaning machine for extra cleaning power. It will also remove pheromones created when your dog urinates, preventing further visits to the same spot.

When the guidelines are followed, it is safe to use around children and pets. It works well for removing older stains, however the stench of the solution may be too strong for certain individuals.

This did not take first place since it does not eliminate pet odors as well as the Simple Solution.


  • Affordable
  • Use on a variety of messes
  • Old stains are removed
  • Prevents further urination
  • Keep children and pets safe


  • Noxious odor

Advanced Option: SIMPLE GREEN Active Stain Enzyme Cleaner

Simple Green Bio Active Stain & Odor Remover for Pet & Carpet

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This non-toxic product is intended to remove difficult stains and odors left by your dog. It is effective on urine, feces, vomit, dirt, and blood. It also works effectively to remove smell marks so your dog does not pee in the same spot again.

Simple Green Enzyme Cleaner is a natural enzyme cleaner that may be used on any porous surface, including rugs, bedding, clothes, and carpets.

It is also suitable for linoleum, tile, wood, laminates, and a variety of other hard surfaces. We enjoy how the product penetrates deep into the cloth to remove stains while leaving no odor or residue.

This cleaner is created in the United States, and the manufacturer backs it up with a 100% satisfaction guarantee, so you may return it if you are not happy.

The Simple Green is more expensive than the Simple Solution and the OUT!, which is why we ranked it third on the reviews list.


  • Non-toxic
  • Removes a wide range of stains
  • Excellent at odor removal
  • Useable on a range of surfaces
  • 100% assurance


  • Pricey

Rocco & Roxie Stain & Odor Remover

 Rocco & Roxie Stain & Odor Eliminator for Strong Odor

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This stain remover is of professional quality and works particularly effectively on carpets. The Carpet & Rug Institute  has rated it as mild and safe for all colorfast carpets.

The company is a tiny family-run operation that stands behind their goods and provides a 100% warranty. It may also be used on other surfaces such as hardwood, tile, and litter boxes.

It is composed of naturally occurring enzymatic bacteria that remove smells and stains. We appreciate that it has no chlorine and is safe to use around dogs and children. On the negative, cleaning with this detergent takes longer.

It is advised that you keep it in place for at least one hour after spraying it on the area to be treated (one with a strong odor), and that numerous applications may be required to thoroughly remove the stain.


  • Excellent for carpeting
  • 100% assurance
  • It may be used on a variety of surfaces
  • Keep dogs and children safe


  • Treatment duration is lengthy

Enzymatic Cleaner with a Simple Solution

 Simple Solution Extreme Pet Stain And Odor Remover

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Simple Solution's enzyme cleanser  is another excellent option because it has excellent cleaning power for a wide range of pet messes.

It is a cheap choice that works well on excrement, urine, vomit, and drool, all of which are problems when you have a dog. It is suitable for use on any water-cleanable surface.

We enjoy the three-in-one sprayer since it lets you pick how the solution is released based on the type of stain or odor to be eliminated.

The foam spray is ideal for entrenched stains since it adheres to the stain and breaks it down. The stream option is more precise and will reach difficult-to-reach regions while offering excellent odor control.

Finally, the mist is ideal for surface stains since it covers a broad area in a single shot.

The Simple Solution contains pro-bacteria and enzymes that remove stains, eliminate smells, and aid in the prevention of future recurrence (such as urinating in one particular area).

It is safe to use around dogs and children when used as advised. We discovered that it works best on fresh stains as opposed to old, set-in stains.


  • Works on a wide range of messes
  • Fewer occurrences (urinating)
  • Sprayer with three functions
  • Affordable
  • Keep dogs and children safe


  • It works best on fresh stains

Commercial Enzymatic Cleaner BUBBAS

 BUBBAS Super Strength Enzyme Cleaner

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BUBBAS Super Strength Enzyme Cleaner  employ natural dormant bacteria that are triggered by ammonia in the urine, and they are more effective and remain longer as a result of their extended slumber.

This cleanser may be used to remove various stains, such as wine, as well as as a pre-wash treatment for your garments.

It is Carpet & Rug Institute-certified, and we found it to be the most effective in removing pee stains from carpet. The directions are clear, however there are several steps to cleaning an old stain.

Apply water to the carpet to soak it into the padding, allow it to rest for five minutes, then dry the excess water, soak the carpet with cleaner, cover with a towel, and leave it overnight.

The price is reasonable, but because you must use a significant amount to remove a stain, you will soon deplete the product if you have a huge area to treat. On the plus side, it comes with a money-back guarantee.


  • Bacteria that are naturally dormant
  • Formula without chlorine
  • Excellent for carpeting
  • 100% assurance
  • Affordable


  • Prolonged cleaning procedure
  • Expensive if there are a lot of areas to clean

Nature’s Miracle Enzymatic Stain &Odor Remover

 Nature's Miracle Advanced Stain and Odor Eliminator Dog for Severe Dog Messes

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Nature's Miracle  is a low-cost enzymatic mixture designed to remove dirt and debris quickly. It is effective in breaking up fresh stains and removing them on contact.

This may be used to collect pee, feces, drool, and vomit. It is not harmful to carpets, hard surfaces, or textiles.

We appreciate the subtle citrus aroma that isn’t overbearing, and it works effectively at removing dog pee stench. On the other hand, it does not remove the real stain.

Unfortunately, the spray nozzle on this device is likewise poorly designed, and it is difficult to maintain accuracy due to the large spray area.

It’s safe to use around dogs and children, and the manufacturer gives a money-back guarantee if you’re not happy.


  • Works quickly
  • Excellent for fresh stains
  • Suitable for a wide range of surfaces
  • Keep dogs and children safe
  • Guaranteed money back


  • Inadequate nozzle design

Enzyme Cleaner ANGRY ORANGE

 Angry Orange Stain Remover - 32oz Enzyme Pet Cleaner

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Angry Orange Odor Eliminator & Pet Stain Remover  has a unique characteristic in that it will operate for up to 80 hours after application – the enzymes are triggered on contact and begin working on removing odor and combating the stain.

It is suitable for use around dogs and children, and it may be used on carpets, litter boxes, furniture, and kennels.

It has a lovely orange scent that is not overbearing, however it leaves an oily residue and the smell fades quickly. Although some people may not want to go to this extra step, soap and water will remove the residue.

It is more expensive than the others on our list, but it is effective in removing old stains and smells from carpet. Angry Orange provides a 100% satisfaction guarantee and will promptly refund your money.


  • Long-lasting formulation
  • Keep dogs and children safe
  • Can be used on a number of surfaces
  • Guaranteed 100% satisfaction
  • Aromatic fragrance


  • Scent fades quickly
  • Greasy residue

Emmy’s Most Effective Pet Odor Remover

 EBPP Odor & Stain Eraser - Made in The USA - Pet Odor Absorber and Room Deodorizer for Home Use

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EBPP Odor & Stain Eraser remove stains, neutralizes smells, and removes pheromones to prevent further soiling. We enjoy how this cleanser eliminates odors rather than disguising them with its lavender aroma.

It will remove pee, feces, and other pet messes from a range of surfaces, including carpets and concrete floors.

The 32-ounce spray bottle is more expensive than others on our list, and we discovered that it did not entirely erase stains or stop your pet from peeing in the same spot as efficiently as other items on our list.

It works quickly to eliminate the stink, and the scent is nice, peaceful, and not overbearing. Emmy’s has a satisfaction guarantee on this product, so if you are unhappy, you can contact them for a return.


  • Formulation with three actions
  • Effectively removes smells
  • Aromatic fragrance
  • Apply to a variety of surfaces


  • Does not completely erase stains
  • Deterrence is ineffective

Pet Odor & Stain Remover Amazing Solutions

 Amaziing Solutions Pet Stain and Odor Remover

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Pet Stain and Odor Remover Enzyme Cleaner  is safe to use around children and pets and is particularly intended for carpets and upholstery.

It is created in the United States of America and contains natural enzymes that neutralize smells and remove stains. It is Carpet and Rug Institute approved and will not stain your carpets.

The directions for Amaziing Solutions are extensive, requiring several procedures to remove an old stain.

We also discovered that repeated applications are required, and that you would need to use a large volume of this cleaner to see benefits.

It is ineffective in preventing your dog from urinating in the same spot, but it does neutralize scents from a human perspective.


  • Certified
  • Keep dogs and children safe
  • Carpet and fabric-specific


  • There are several stages to cleaning stains
  • Repetitive applications are necessary
  • It does not prevent repeated soiling

Pet Urine Enzymatic Cleaner Smiling Paws

 Smiling Paws Pets Cat Urine Odor Eliminator

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The Smiling Paws cleaner is constructed of a cutting-edge bio-enzyme combination and may be used on a range of surfaces, including carpet, rugs, and hardwood floors.

It’s great for getting rid of pet stains and odors caused by urine, feces, and vomit.

This cleaner features a non-toxic solution that is safe to use around pets, and the family-run firm gives a money-back guarantee if you don’t like the product.

The spray nozzle, on the other hand, is ineffectual and cannot be changed to make the stream more precise.

This product has a strong flowery perfume that does not disperse quickly, thus it hides the smell but does not eradicate it, nor does it prevent recurrent soiling.


  • Blend of bio-enzymes
  • Apply to a variety of surfaces
  • Non-toxic


  • Spray nozzle that is ineffective
  • Smell that is overpowering
  • Does not remove pee odor
  • It does not prevent repeated soiling

Buyer's Guide: Choosing the Best Dog Urine Enzyme Cleaners

When looking for an enzyme cleanser for dog pee, there are a few things to keep in mind to help you choose the best one for your needs.

Remember that dogs have a greater sense of smell than people, and if any scent pheromones remain in the vicinity, they will be drawn to it. Finding the finest enzyme cleanser for dog pee ensures that you will not have any troubles in the future.



You should be aware of the cleaner’s composition; if you intend to use it around pets and children, it should be non-toxic and free of ammonia and/or bleach.

In reality, remedies containing those two chemicals might aggravate the problem of your dog urinating in a certain location.

The enzymes that break down the protein in the stain should be the main element. Most are environmentally safe and have a neutral pH level, which aids with odor control.

Certain enzymes continue to function after being left on the surface for an extended amount of time.

Many have perfumes to create a fresh scent; the sort of fragrance you pick will be determined by your particular preferences.


This covers the number of surfaces it can be used on as well as the sorts of problems it can clean up. If your dog urinates on the carpet, look for an enzymatic cleaner designed for carpets.

If the sofa is the primary gathering place, an enzyme cleaner designed for upholstery might be appropriate.

Utilization Ease

This is critical, especially if you don’t have a lot of time on your hands. Some formulations are designed to work rapidly and are great for fresh stains and messes, but others must sit for extended periods of time to dissolve old stains.


Price may or may not be a concern, but consider how frequently you’ll need to use the enzyme cleanser and how much is needed in a single cleaning session.

If you have to apply it numerous times to remove one stain, it can quickly become expensive since you have to buy greater volumes. In contrast, if it is a terrific cleanser and does the job the first time, you may splurge on a more expensive kind.

Useful hints when utilizing enzyme cleaners:

  • It is better to utilize them as soon as possible once the mess occurs.
  • For the best results, read and follow the instructions.
  • To ensure that the enzymatic cleaner does not harm the surface, test it on a tiny area first.
  • A UV light may be used to find urine and determine whether any remains after cleaning.


You like your dog, but it might be tough to remain optimistic when your home smells like pee. Using an enzyme cleanser to get rid of urine odors and stains can save your property and your sanity.

The best cleaner to get rid of dog urine is the Hepper Advanced Bio-Enzyme Pet Stain & Odor Eliminator Spray , which is safe for pets and can be used on many surfaces.

OUT!  The best value is dog detergent, which is cheap and gets rid of hard-to-clean stains and keeps dogs from peeing in the same spots.

If price isn’t an issue, Simple Green is a great way to get rid of strong smells and tough stains while using a non-toxic formula.

BestForPets (bestforpets.org) would like to thank our customers for visiting our website so I could learn about and recommend the best enzyme cleaners for dog urine.

We hope that our list of reviews and buyer’s guide to the best enzyme cleaners for dog urine will help you find the best enzyme cleaner for you that is easy to use.

With your wallet, get the job done so you can enjoy the advantages of dog ownership without worrying about unattractive stains and unpleasant odors.

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Dr. Elsa Fabian

Dr. Elsa Fabian, DVM, is a qualified veterinary and medical editor with seven years of experience and a Doctor of Veterinary Medicine degree. She has edited approximately 700 projects, such as research papers published in academic publications, continuing medical education training materials, and pet health articles.

Veterinarian (DVM) Dr. Elsa Fabian


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