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The 12 Best Dog Calming Supplements For Anxiety & Stress

Numerous anti-anxiety drugs are available for dogs since numerous breeds deal with anxiety concerns. Whether their challenge stems from behavioral disorders or traumatic and unpleasant experiences, achieving their goal of being happy and healthy may require supplements.

Finding the appropriate medicine to effectively manage the mental health of a dog can be time-consuming. Not all supplements for canine anxiety are made equal, and each dog may react significantly differently.

To assist you in determining what will work best for your dog, BestForPets (bestforpets.org) has reviewed the best dog calming supplements for anxiety & stress.


PetHonesty Hemp Calming Supplement for Dogs

Recently, products produced from the hemp plant have attracted widespread attention due to their legalization and safer usage as a result of supervised manufacturing. The plant generates several distinct chemical substances.

Psychoactive properties are a result of THC. CBD is nonpsychoactive and may be taken safely to maintain a tranquil state of mind. It is frequently used to treat anxiety symptoms since it has a calming effect on both people and animals.

This product manufactured by PetHonesty is derived from hemp and uses CBD to relax your dog. It can be used to calm them if they exhibit normal anxiety symptoms or are hyperactive. It may be utilized to make it simpler for your dog to access public areas without incident.

This product comprises natural herbal components derived from organic hemp and chamomile and is effective within 30 to 45 minutes. The supplement has no medications or sedatives, nor does it include maize, wheat, soy, or GMOs.

These supplements are FDA-registered and manufactured in a GMP-certified facility in the United States. The soft chews feature a natural chicken flavor and are flavored with chicken. This facilitates administration to your dog.


  • All-natural remedy for hyperactivity, anxiety, and stress
  • Registered with the FDA and wholly manufactured in the United States.
  • Works in less than 45 minutes


  • Some pet owners have misgivings about hemp products.


Thunder Wunder Calming Chews

This product is derived from hemp and employs the relaxing effects of herbs. Other herbs besides hemp seeds are recognized for their relaxing qualities. Included in this category are chamomile, passionflower, thiamine, ginger, and melatonin.

This product is recommended by ThunderWunders if your dog is terrified of thunder and pyrotechnics. ThunderWunder chews can help dogs relax if they suffer from separation anxiety, are not excellent travelers, or detest being transported to the vet or groomer.

Depending on the quantity purchased, each container contains 60 or 180 soft chews. The 100% satisfaction guarantee plus the fact that they are the most cost-effective dog calming supplements for anxiety and stress allow you to test them risk-free.

Depending on the size of your dog, you will need to provide more chews to achieve the required outcomes. It should not be administered to puppies less than 12 weeks.

If your dog weighs less than 26 pounds, it should only consume one chew every 12 hours. If they weigh between 27 and 50 pounds, they can eat two. Dogs up to 100 pounds can have four chews every 12 hours, while those above 100 pounds can have six. There is no need to exceed these doses.


  • Drug-free formulation to safeguard your cat
  • Rapid-acting soft chew to promote tranquil responses
  • The best option for a cheap buy


  • Not all pet owners have faith in hemp products.


Calming Care for Dogs from Purina

Possibly your dog has battled with anxiety or hyperactivity for a significant portion of its life, and you want to do all possible to alleviate its emotional suffering.

If you choose a premium choice, the Purina Pro Plan Calming Care Supplement is ideal. This medication is frequently recommended by veterinarians as a nutritional supplement to improve coping mechanisms during stressful conditions.

The 6-week supply of Purina Pro Plan Soothing Care Supplements is packaged in a box and is formulated with a probiotic strain recognized for its calming impact on dogs. It is known as BL999 and has been proven to be an excellent stress treatment.

This dietary supplement is simple to provide to your dog because it is an extremely appetizing meal topper. You open the sachet and sprinkle the contents over the top of their dish in order to get the desired result. It also helps individuals maintain a healthy heart rate if they begin to feel worried.

This product is an excellent choice for dogs with excessive barking, hyperactivity, or separation anxiety. BL999 is the single active component, whereas liver flavor and maltodextrin are the two inactive ones. You can feed them up to one packet each day, but it is advisable to get your veterinarian’s approval first.


  • For individuals who are uneasy with such items, it does not include narcotics or hemp.
  • Veterinarian-recommended
  • Includes a six-week supply when used daily.


  • A premium product carries a premium cost.


Calming Bites from Zesty Paws for Stress and Anxiety

Even when a dog is calmer, this does not mean that they have lost their passion for life. This is precisely what Zesty Paws encourages with their relaxing treats designed to assist your dog manage stress and anxiety.

Each container contains 90 soft chews. You should begin by administering half of the recommended daily dose. This will be one to three chews each day, depending on their weight. If required, gradually increase the daily dose. You may even divide the dosage between morning and evening to spread the effects throughout the day and into the evening.

These peanut butter-flavored chews are suitable for dogs of all ages and are a tasty treat for your pet. They are intended to assist stressed, anxious, or hyperactive puppies.

In this composition, the active components are derived from plants. There are also chamomile, valerian root, Sensoril ashwagandha, and L-tryptophan. In addition, they contain Suntheanine, an amino acid that promotes relaxation in your dog. These chews can assist dogs cope with stressful conditions such as thunderstorms, fireworks, and other scenarios.


  • Peanut butter-flavored soft chews that are palatable.
  • Containing Suntheanine
  • Available in a 90-count container.


  • Contains contentious hemp powder and extract


Pet Naturals of Vermont Tranquilizers for Dogs

This relaxing dog chew is made in Vermont by Pet Naturals, a small, family-owned firm that believes in assisting dogs in overcoming mental and emotional stress.

It is completely natural and should not be mistaken for a sedative. Instead of putting your dogs to sleep, you should relax them and make them feel more comfortable in stressful situations. These chews are designed with the assistance of veterinarians and are incredibly tasty, making them simple to administer to your dog.

These chews include the active components thiamine, C3 or Colostrum Calming Complex, and Suntheanine-brand L-Theanine. Among the inactive components are brewer’s yeast and canola, vegetable oil for texture, and a chicken liver flavoring for flavor.

It is fine to give your dog one chew each day, and if they are experiencing significant stress, you can double or quadruple the amount. However, the doses are not indicated as varying according to breed size. This is a problem for owners of very large or small canines.


  • Limited and noncontroversial active compounds
  • Developed by veterinaries
  • Vermont-made within the United States.


  • There are no weight-based dosage guidelines for dogs.


HomeoPet Anxiety Relief Dog Supplement

HomeoPet promotes its product as a natural remedy for anxiety relief. They wish to alleviate the anxiety that usually results from separation when an animal is kenneled or is apprehensive about seeing the veterinarian or groomer.

This product is not exclusive to dogs. It may be administered safely to cats, birds, and even rabbits. It helps them deal with barking, crying, disruptive behavior, panting, and plucking feathers (for a bird).

This product is available in liquid form. It is administered to your pet as drops, either orally or with their food or drink. It is a chemical-free recipe containing only natural and pure components. Based on years of study, the combination has not yet shown any adverse consequences. It is not a sedative, but rather a soothing substance intended to provide relief to your animals.

These homeopathic drops for anxiety are FDA-approved. Calcarea phosphorica, lycopodium, phosphorus, and staphysagria are some of the principal constituents. The product takes between 15 and 20 minutes to take action. There are conflicting opinions as to whether or not it works on dogs.

The dose for cats and dogs is determined by their body weight. They may safely take 5 to 20 drops once a day, in divided doses. When the individual’s symptoms have subsided, it is preferable to cease the use of the product. It is preferable that a veterinarian’s suggestion accompany this product.


  • Easily delivered in the form of liquid droplets
  • All-natural formula
  • Compatible with a broad variety of animals


  • Mixed opinions about the usefulness of dogs


Vet’s Best Comfort Calm Dog Supplement

Vet’s Best Comfort Calm Chews are available in packages of 30 or 90 chews. As the name suggests, this medicine is suggested by veterinarians, who developed the formula to produce a solution that would not promote sleepiness in pets. They are able to resume their everyday routines with reduced anxiety symptoms.

The chews are composed mostly of plant-based components. Included in this category are tryptophan, valerian root, chamomile, thiamine, ginger root, and sea kelp.

To make it an even healthier, immunity-boosting snack, antioxidants and prebiotics have been added. These compounds’ bioavailability has been carefully tuned to make them as potent and fast-acting as feasible.

The components are not entirely American, though. Instead, they are obtained overseas, and although the corporation tells purchasers that they originate from reliable sources, we cannot be certain due to regulations in those nations.

The chews are extra-moist and flavored with the chicken liver that has been dehydrated. It is gently sweetened with sugar cane molasses. Depending on their weight, you only need to feed your pet a maximum of two chews every day. It has the National Animal Supplement Council’s stamp of approval and is completely gluten-free.


  • Plant-based and gluten-free ingredients
  • Encourage balanced conduct
  • Veterinarian-formulated for bioavailability


  • Ingredients obtained internationally


Calming Nutramax Solliquin Chews

Nutramax Solliquin Calming Soft chews are available in a sealed packet of 75 chews for both dogs and cats. These chews are behavioral health supplements designed to help dogs remain calm in stressful conditions. These treats may assist with hyperactivity and barking problems.

Although you may purchase this tranquilizer online, it is advisable to obtain it from your veterinarian, as they will be able to advise you on the proper dosage and brand. The majority of these chews’ components are plant-based.

This product is part of a complete treatment program from Nutramax, which promises that, when combined with patience and training, these chews may avoid the majority of anxiety-related behavioral issues.

The chews are suitable for regular usage. It takes time for them to enter your dog’s system and provide a general feeling of well-being. For long-term outcomes, the suggested first dosing duration for these chews is between 30 and 45 days.

These supplements contain extracts of Magnolia officinalis and Phellodendron amurense as active components. L-Theanine and dry whey protein concentrate are the others. The flavor is derived from an unknown “natural flavor.”


  • Potential long-lasting relaxing effects
  • Mostly all-natural ingredients


  • Not all components are transparent.


waggedy Calm Supplement for Stress and Anxiety Relief for Dogs

This Waggedy product is intended to reduce tension and anxiety. The symptoms may be caused by storms, fireworks, travel, or vet and grooming appointments. It is a reasonably inexpensive alternative best suited for budget-conscious customers. The supplement comes in the shape of soft chews, and each container contains sixty.

These chews include chamomile, thiamine mononitrate, ginger, passionflower, L-Tryptophan, and melatonin as active components. Humans commonly utilize melatonin as a sleep aid since it is known to induce sleepiness. It may have a little sedative effect on your dog following administration.

Waggedy’s supplements are made in the United States and may be simply provided as a reward due to their overall palatability. The natural flavor is not indicated on the list of ingredients, although it is often appealing to dogs.

The quantity of chews you give your dog is proportional to its weight. They will require one to six chews, and only dogs older than 12 weeks should receive any.

It takes around 30 minutes to become effective; therefore, it should be taken at least 30 minutes before to an anticipated stressful circumstance. Under no circumstances should you exceed a double dose within a 12-hour time frame.


  • Plant-based active compounds sourced from nature
  • Highly appealing texture and flavor


  • Due to the active component melatonin, this product might induce sleepiness.
  • Natural flavour not listed in the ingredients


PL360 Anxiety Relief Supplement for Dogs

The supplement PL360 Anxiety Relief for Dogs comes in a tiny canister or pill container. There are sixty soft chews in each container, and their natural beef flavor makes them tasty.

You may rely on PL360 if you need assistance calming down your stressed-out dog. It contains only natural components, making it chemical-free and safe for consumption by your pet.

Chamomile, passionflower, GABA, thiamine, and ginger root powder are the active components. The very few inactive components are beef flavor, liver powder, brewer’s yeast powder, and preservative chemicals.

These chews should not be given to puppies younger than 14 weeks of age. They are successful when taken in combination with a behavior change program. On the back of the bottle is a dosage guideline that should be carefully followed based on your dog’s weight.

This product developed in the United States contains natural substances such as chamomile and tryptophan to support the health and well-being of dogs. However, their efficacy has received a variety of opinions.


  • Made in the United States of America
  • All-natural ingredients


  • Mixed opinions regarding the efficacy

Buyer's Guide

No one enjoys seeing their dog anxious or worried. If you have trouble getting your dog to settle down, a soothing supplement might be the answer. Some are more successful than others, while others contain chemicals you may not feel comfortable giving your dog.

Before making a purchase, keep these considerations in mind while you peruse the various options to soothe your dog.

Natural Ingredients or Not?

Long term, supplements can be beneficial for your dog, but they can also be potentially hazardous. They may include a variety of substances, including preservatives and chemical additions. If you are like most dog owners, you do not want to give your pet a pill or chew containing unidentified components.

Pay close attention to the ingredient list and research the function of each item. It is preferable to err on the side of caution, especially if your dog is sensitive to specific foods or substances.

If your dog has a bad reaction to a supplement that you’ve given them, you should investigate the cause. You must determine which elements are ineffective so you can avoid them in the future.

Form of Administration

There are several methods for getting an animal or human to take medicine. You are aware of the substances that your dog may and cannot consume. If you want to avoid hours of frustration or a product that is virtually worthless because you can’t get your dog to ingest it, you should try many types of dog food before purchasing one.

The most frequent method of administration for calming supplements is the oral consumption of a treat-like soft chew. As long as it tastes nice, it will work well for the majority of dogs, as they enjoy treats and are not picky eaters. For others, you may need to be more stealthy. You may, for instance, include liquid droplets in their food or drink.

Duration of Supply

Some individuals have quite large dogs, and you do not wish to purchase a new bottle every two weeks. Consider the size to see whether it would be a cost-effective solution for your dog’s anxious behavior. You may even be able to order it in large quantities.

Time Before Acting

All medications and supplements will affect each dog differently. If you want to be able to plan travels or prepare for difficult days, you should consider the amount of time the maker says it will take to notice the impact.

Some supplements are intended for long-term use as opposed to quick results. However, the majority of supplements become effective within 15 to 30 minutes after consumption.

Ingredient Procurement

Lastly, just though the ingredient list appears acceptable does not guarantee that the products are completely safe. If the corporation obtains its ingredients from foreign nations, it may not be subject to the same manufacturing and quality standards as those in the United States.

This implies that certain components may be of low quality, may have been cultivated with excessive levels of chemicals, or may not have been delivered to preserve their efficacy.


PetHonesty’s Hemp Calming Dog Supplement is a good place to start if you are seeking one of the highest-rated products currently available on the market. Or perhaps you require a cost-effective alternative before committing to this treatment plan. Consider ThunderWunders Hemp Calming Dog Treats.

Trying out a new supplement to keep your dog calmer can be beneficial for both you and your dog. Nonetheless, initial doubt is inevitable. In order to avoid giving your dog needless drugs, it is essential to acquire a recommendation from your veterinarian before purchasing any of these items. BestForPets (bestforpets.org) hopes that our reviews of the best dog calming supplements for anxiety & stress have assisted you in narrowing down your selections and identifying the ideal product for your needs.

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Dr. Deborah Fletcher

Deborah R. Fletcher, DVM, is a skilled veterinarian with more than 15 years of experience dealing with companion and exotic animals. She has experience caring for a variety of animals, including household cats and dogs, reptiles, birds of prey, and even primates. Dr. Fletcher is a valuable part of the BestForPets team, where she contributes to their aim of providing pets and their owners with the finest possible treatment and services.

Veterinarian (DVM) Dr. Deborah Fletcher


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